Inhibition of interferon secretion by vinblastine
Open Access
- 1 March 1975
- journal article
- Published by Rockefeller University Press in The Journal of cell biology
- Vol. 64 (3), 716-719
- https://doi.org/10.1083/jcb.64.3.716
Abstract
The plant alkaloids vinblastine and colchicine are known to arrest cells in mitosis by virtue of their binding to spindle protein. These drugs are also capable of binding to microtubule protein and causing these structures to disaggregate into nonfunctional subunits (1, 2). Microtubular structures are thought to be involved in the secretory process of a number of proteins including insulin (7), collagen (4), and thyroid hormone (12). In this report we present our findings on the effects of these two drugs on the synthesis and secretion of interferon in a high producing human foreskin fibroblast strain (FS-4) (11).Keywords
This publication has 12 references indexed in Scilit:
- Stabilization of Interferon Messenger RNA Activity by Treatment of Cells with Metabolic Inhibitors and Lowering of the Incubation TemperatureProceedings of the National Academy of Sciences, 1973
- Early events in the interaction of adenoviruses with HeLa cellsVirology, 1973
- Production of High-Titered Interferon in Cultures of Human Diploid CellsAntimicrobial Agents and Chemotherapy, 1972
- Nucleoside transport in mammalian cells. Inhibition by colchicineBiochemistry, 1972
- Inhibition of Collagen Secretion from Bone and Cultured Fibroblasts by Microtubular Disruptive DrugsProceedings of the National Academy of Sciences, 1972
- Intracellular interferon: Kinetics of formation and releaseVirology, 1971
- Possible Role of Microtubules in Thyroid SecretionProceedings of the National Academy of Sciences, 1970
- Precipitation of Proteins by Vinblastine and Calcium IonsProceedings of the National Academy of Sciences, 1970
- Depression of DNA synthesis and mitotic index by colchicine in cultured human lymphocytesExperimental Cell Research, 1970
- New Hypothesis of Insulin SecretionNature, 1968