Exposure of Rats to Alcohol in Utero Alters Drug Sensitivity in Adulthood
- 26 June 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 212 (4502), 1531-1533
- https://doi.org/10.1126/science.7233243
Abstract
Pregnant rats were intubated with alcohol (ethanol, 3 grams per kilogram) twice daily throughout gestation. Control animals received solutions of isocaloric sucrose. At birth, offspring were placed with untreated surrogate dams. Beginning at 6 months of age, the offspring were tested for their thermogenic responsiveness to various drugs and to cold. Prenatal exposure to alcohol resulted in tolerance to alcohol and cross-tolerance to pentobarbital and diazepam but did not affect responsiveness to cold. This pattern of effects suggest that prenatal exposure to alcohol produces specific long-term effects on the neural mechanisms underlying drug tolerance.This publication has 13 references indexed in Scilit:
- Effects of beer, wine, whiskey, and ethanol on pregnant rats and their offspringTeratology, 1981
- Open-field and avoidance performance of rats as a function of prenatal ethanol treatmentAddictive Behaviors, 1979
- Cross-tolerance between ethanol and morphine with respect to their hypothermic effectsEuropean Journal of Pharmacology, 1979
- Effects of alcohol withdrawal and undernutrition on cannibalism of rat pupsBehavioral and Neural Biology, 1979
- Prenatal effects of alcohol on adult learning in ratsPharmacology Biochemistry and Behavior, 1979
- The Fetal Alcohol SyndromeNew England Journal of Medicine, 1978
- Ethanol‐Induced Malformations in MiceAlcohol, Clinical and Experimental Research, 1977
- Acquisition and loss of behaviorally augmented tolerance to ethanol in the ratPsychopharmacology, 1976
- Acute tolerance to diazepam in cats and its possible relationship to diazepam metabolismEuropean Journal of Pharmacology, 1971
- Induction of Liver Acetaldehyde Dehydrogenase: Possible Role in Ethanol Tolerance after Exposure to BarbituratesScience, 1971