Mutants of bacteriophage lambda able to grow on the restricting host Escherichia coli strain W
- 1 February 1967
- journal article
- research article
- Published by Hindawi Limited in Genetics Research
- Vol. 9 (1), 129-133
- https://doi.org/10.1017/s0016672300010405
Abstract
Escherichia coli strain W adsorbs phage λ very efficiently but the phage does not form plaques on this strain because the DNA of λ is broken down in a majority of the infected cells shortly after adsorption. In a 10−3 to 10−4 fraction of the infected cells λ grows and small bursts of phage are produced. This phage does not carry the W-specific host modification and is unable to complete a second round of infection in W (Kerszman, Glover & Aronovitch, 1967). λω mutants have been isolated which are able to escape this restriction process and which plate on W with an efficiency of 1·0 and when grown in W these mutants carry a W-specific host modification.Keywords
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