Possible neurotransmitter basis of behavioral changes in alzheimer's disease
- 1 June 1988
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 23 (6), 616-620
- https://doi.org/10.1002/ana.410230616
Abstract
Serotonin, 5-hydroxyindoleacetic acid, and homovanillic acid concentrations have been determined in 10 areas of the cerebral cortex from 17 subjects with Alzheimer's disease and 18 control subjects. The dopamine metabolite was not reduced in any area, whereas both indoleamines were reduced in the superior frontal, inferior temporal, and fusiform gyri, and the temporal pole. These areas and areas of the parietal cortex, where there were no changes in concentration, have not previously been reported on. We argue that the large loss of indoleamines from the frontal lobe (to 50–63% of control values) is rather unexpected based on other biochemical measurements and may relate to behavioral changes.Keywords
This publication has 14 references indexed in Scilit:
- Aminergic systems in Alzheimer's disease and Parkinson's diseaseAnnals of Neurology, 1987
- Catecholaminergic neurones assessed ante-mortem in Alzheimer's diseaseBrain Research, 1987
- Intercorrelations of regional cerebral glucose metabolic rates in Alzheimer's diseaseBrain Research, 1987
- Monoaminergic innervation of the frontal and temporal lobes in Alzheimer's diseaseBrain Research, 1987
- Presynaptic Serotonergic Dysfunction in Patients with Alzheimer's DiseaseJournal of Neurochemistry, 1987
- Critical Appraisal of the EvidenceAnnals of the New York Academy of Sciences, 1986
- The cerebral cortical appearance in depressed subjectsPsychological Medicine, 1986
- Binding of the Novel Serotonin Agonist 8‐Hydroxy‐2‐(Di‐n‐Propylamino) Tetralin in Normal and Alzheimer BrainJournal of Neurochemistry, 1986
- Biochemical Assessment of Serotonergic and Cholinergic Dysfunction and Cerebral Atrophy in Alzheimer's DiseaseJournal of Neurochemistry, 1983
- Mood change following left hemispheric brain injuryAnnals of Neurology, 1981