No Correlation between A(–1438)G Polymorphism in 5-HT2A Receptor Gene Promoter and the Density of Frontal Cortical 5-HT2A Receptors in Schizophrenia
- 1 March 1999
- journal article
- research article
- Published by S. Karger AG in Human Heredity
- Vol. 49 (2), 103-105
- https://doi.org/10.1159/000022853
Abstract
The A(–1438)G promoter polymorphism of the 5-hydroxytryptamine 2a receptor (5-HT2AR) gene and its influence on the cortical density of 5-HT2AR was studied using brain tissue donated at autopsy from 58 schizophrenic and 64 non-schizophrenic subjects. A linkage between genotypes for the A(–1438)G and a T102C polymorphic site identified in a previous study was observed. Our data suggest no association of the A(–1438)G polymorphism with schizophrenia and no effect of the promoter genotype upon 5-HT2AR densities in either the schizophrenic or non-schizophrenic groups.Keywords
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- No association or linkage between the 5‐HT2a/T102C polymorphism and schizophrenia in Irish familiesAmerican Journal of Medical Genetics, 1997