SYNTHESIS OF CERTAIN 4′‐SUBSTITUTED NUCLEOSIDES*
- 1 August 1975
- journal article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 255 (1), 151-165
- https://doi.org/10.1111/j.1749-6632.1975.tb29220.x
Abstract
We have developed general methods for the synthesis of 4'-fluoro- and 4'-methoxynucleosides by addition of iodinemonofluoride or iodine and methanol across the double bond of suitably protected 4',5'-unsaturated pyrimidine and purine nucleosides. The structures of these adducts have been determined by a combination of chemical, spectroscopic, and electrophoretic methods. The 4'-methoxy- and the uridine analogs of nucleocidin have been synthesized from the corresponding 4'-fluorouridine and 4'-methoxyadenosine derivatives.This publication has 32 references indexed in Scilit:
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