Neurosyphilis, the search for adequate treatment. A review and report of a study using benzathine penicillin G

Abstract

The search for adequate penicillin treatment in patients with active neurosyphilis was reviewed. Only studies giving data obtained by spinal fluid examination were discussed. Most studies in which patients were observed for an adequate length of time following treatment report a failure rate of approximately 10% within 2 years, regardless of the form or amount of penicillin given. A study using benzathine penicillin-G 4,800,000 units in patients with active neurosyphilis was reported. Twenty-six patients were treated: 23 were followed 1 year or more and 17 for 2 years or longer. Two patients failed to respond to this dosage. The results are comparable to those obtained with other schedules and forms of penicillin.