Anti-Aids Agents, 3. Inhibitory Effects of Colchicine Derivatives on HIV Replication in H9 Lymphocyte Cells

Abstract

A series of colchicine and isocolchicine derivatives were evaluated as inhibitors of HIV replication in H9 lymphocytes. Colchicine showed only very slight inhibition in the absence of toxicity, as measured by the therapeutic index (IC50/EC50). None of the derivatives inhibited HIV replication in the absence of toxicity.