The Effects of Combined Platelet and Leukapheresis on the Blood Coagulation System

Abstract

Analysis of blood coagulation was done on samples of blood collected from 10 donors undergoing combined platelet and leukapheresis using the Hemonetics Model 30 Blood Processor. Blood samples were obtained from the donors prior to, during and following pheresis. Blood was also obtained from the blood-return line after the first collection of leukocytes and platelets, but before it was returned to the donor. Although the citrate anticoagulant was returned to the donor and there were some decreases in the concentrations of fibrinogen, platelets and factors V and VIII, there were no changes of sufficient degree to suggest the development of a potential bleeding disorder. There was no evidence to suggest that any activation of blood coagulation occurred during the pheresis or that thrombogenic substances were returned to the donors. Combined platelet and leukapheresis using the Hemonetics Model 30 Blood Processor apparently do not subject the donor to risks for bleeding or thrombotic complications.