What is the difference between squamous cell carcinoma and adenocarcinoma of the cervix? A matched case–control study
- 1 July 2006
- journal article
- research article
- Published by BMJ in International Journal of Gynecologic Cancer
- Vol. 16 (4), 1569-1573
- https://doi.org/10.1111/j.1525-1438.2006.00628.x
Abstract
The objective of this study was to investigate the efficacy of treatment strategies in patients with adenocarcinoma (AC) of the cervix and compare it with those with squamous cell carcinoma (SCC) of the cervix. Women with FIGO (1994) stage IB1 AC, especially pathologic tumor size of 2-4 cm, treated with class III hysterectomy, were compared with those with SCC treated with comparable strategy in a case-controlled study. Eighty patients (20 cases, 60 controls) were analyzed. Lymphvascular space invasion (P = 0.01) and lymph node metastasis (P = 0.07) were more frequent in patients with SCC than in those with AC. However, there was no significant difference in depth of stromal invasion (P = 0.51) and invasion of the parametrium (P = 0.44) between two groups. And there was also no statistically significant difference in disease-free survival (P = 0.86) and overall survival (P = 0.89) between two groups. Primary radical surgery followed by adjuvant therapy, same as for SCC, would be acceptable for AC with pathologic tumor size of 2-4 cm. Although it was difficult to determine whether AC recurred more systemically, more effective treatment strategies than those currently available for AC should be considered to reduce the systemic recurrence.Keywords
This publication has 23 references indexed in Scilit:
- A comparison of prognoses of FIGO stage IB adenocarcinoma and squamous cell carcinomaInternational Journal of Gynecologic Cancer, 2004
- Is There a Difference in Survival for IA1 and IA2 Adenocarcinoma of the Uterine Cervix?Gynecologic Oncology, 2002
- A Comparison of Prognoses of Pathologic Stage Ib Adenocarcinoma and Squamous Cell Carcinoma of the Uterine CervixGynecologic Oncology, 2000
- The Rising Incidence of Adenocarcinoma Relative to Squamous Cell Carcinoma of the Uterine Cervix in the United States—A 24-Year Population-Based StudyGynecologic Oncology, 2000
- Prognosis and clinicopathological characteristics of Ib-IIb adenocarcinoma of the uterine cervix in patients who have had radical hysterectomyEuropean Journal of Surgical Oncology, 2000
- Randomised study of radical surgery versus radiotherapy for stage Ib-IIa cervical cancerThe Lancet, 1997
- An Analysis of Cell Type in Patients with Surgically Staged Stage IB Carcinoma of the Cervix: A Gynecologic Oncology Group StudyGynecologic Oncology, 1996
- Long-Term Follow-Up of Stage I Cervical Adenocarcinoma Treated by Radical SurgeryGynecologic Oncology, 1994
- Adenosquamous Carcinoma of the Cervix: Prognosis in Early Stage Disease Treated by Radical HysterectomyGynecologic Oncology, 1993
- Prospective surgical-pathological study of disease-free interval in patients with stage IB squamous cell carcinoma of the cervix: A Gynecologic Oncology Group studyGynecologic Oncology, 1990