LYMPHOGRANULOMA venereum and particularly strictures of the rectum caused by this disease have been the subject of many reports in recent years. It is generally recognized that the anorectal manifestations of this widespread disease offer the most serious threat to life and are, likewise, most difficult to treat satisfactorily. At Harlem Hospital we have had an opportunity to study a large number of cases of fibrous inflammatory strictures of the rectum, and this paper is a study of 476 consecutive cases in which patients were admitted to the wards of the hospital during the fifteen and a half year period from Jan. 1, 1930, to Aug. 1, 1945. The more attention we have given this disease, the more we have come to realize that our knowledge is still extremely incomplete and that increased clinical and laboratory study is needed to clear up many aspects of the subject. Some clinical aspects