The interaction of hemicholinium-3 and oxotremorine in isolated organ preparations

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Abstract
On isolated ileum preparations of the rat and guinea-pig, hemicholinium-3 antagonizes contractions elicited by acetylcholine and oxotremorine to the same extent. Hemicholinium-3 was a mild antagonist to acetylcholine but a stronger one to oxotremorine and carbachol on the ileum of the rabbit. Whereas hemicholinium-3 has no anti-acetylcholine activity on the isolated urinary bladder of the rat, it antagonizes the contractions elicited by oxotremorine and carbachol, and acetylcholine after eserine. Morphine has an anti-oxotremorine activity on this organ. Increasing concentrations of oxotremorine release increasing amounts of acetylcholine from the rat isolated intestine.