Dimethylsulfoxide-induced differentiation and hemoglobin synthesis in tissue cultures of rat erythroleukemia cells transformed by 7,12-dimethylbenz(a)anthracene.
- 1 April 1976
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 73 (4), 1237-1240
- https://doi.org/10.1073/pnas.73.4.1237
Abstract
Permanent cell lines from transplantable tumors from 7,12-dimethylbenz(a)anthracene-induced erhthroleukemia of the rat were established. These cell lines maintain their erythroid nature. Erythroid differentiation can be induced by dimethylsulfoxide. This is shown by decrease in cell size, appearance of red and benzidine positive cells, and induced synthesis of 4 out of 6 adult globin chains.This publication has 14 references indexed in Scilit:
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