PLASMA-LEVELS OF DI-N-PROPYLACETATE AND CLONAZEPAM IN EPILEPTIC PATIENTS

Abstract

Plasma levels of DPA [di-n-propylacetate] and CNP [clonazepam] and associated antiepileptic drugs were measured in groups of 106 and 30 epileptic patients aged from 3-49 yr. A poor correlation between daily oral doses and plasma levels of both drugs was observed when the whole group of patients was considered. A better correlation was seen in a group of adult patients who received DPA and PB (phenobarbital). Children below 10 yr of age disposed both drugs faster than adults, and the difference was significant (P < 0.01) in groups receiving PB as associated drug. Patients medicated with PB and DPA or CNP showed lower plasma levels of both drugs; DPA appeared to cause a decrease of PB clearance which was more marked in children. The clinical significance of fluctuations of daily plasma levels of both drugs were discussed in relationship to the schedule of administration and plasma sampling. Observations on therapeutic ranges and adverse effects of the drugs were reported.