DEFICIENT ACTIVITY OF RECEPTOR-CYCLASE COUPLING PROTEIN IN PLATELETS OF PATIENTS WITH PSEUDOHYPOPARATHYROIDISM
- 1 November 1980
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 51 (5), 1202-1204
- https://doi.org/10.1210/jcem-51-5-1202
Abstract
Erythrocytes of patients with pseudohypoparathyroidism exhibit decreased activity of a membrane protein that is required for functional coupling of hormone receptors and catalytic adenylate cyclase. We observed decreased activity of this coupling protein in platelet extracts obtained from two pseudohypoparathyroid subjects, as compared with those of four normal control subjects. These findings support the hypothesis that generalized deficiency of this coupling protein is the primary biochemical defect of pseudohypoparathyroidism.Keywords
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