Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. II. Evaluation in Adult Volunteers
- 1 December 1980
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 142 (6), 857-860
- https://doi.org/10.1093/infdis/142.6.857
Abstract
A cold-recombinant influenza A virus, CR 22, derived from A/Ann Arbor/6/60 (H2N2) cold-adapted virus and A/Victoria/3/75 (H3N2) wild-type virus, was tested in adult volunteers. CR 22 induced only low-grade clinical reactions in volunteers who had low titers of serum antibodies. Virus could be reisolated from about one-third of the volunteers-but only at low titers. No revertant viruses were found, and there was no evidence for transmission of virus to unvaccinated volunteers housed in close contact with the vaccinees. A high proportion of the volunteers seroconverted, and the mean titers of serum antibody after immunization suggest that a high degree of protection is induced by vaccination with live CR 22 virus.Keywords
This publication has 2 references indexed in Scilit:
- Studies with a Cold-Recombinant A/Victoria/3/7S (H3N2) Virus. I. Biologic, Genetic, and Biochemical CharacterizationThe Journal of Infectious Diseases, 1980
- Temperature-Sensitive Mutants of Influenza A Virus: Evaluation of A/Victoria/3/75- ts -1[E] Recombinant Viruses in VolunteersInfection and Immunity, 1978