Hyperphagic hyperreactivity to adulteration of drinking water with quinine HCL.

Abstract

After a pretest base line of water intake was established, normal and obese hyperphagic rats were presented a bitter solution of 0.025% quinine HC1 as their only source of fluid for 5 days. Hyperphagics drank almost no quinine water during the 5-day test period. Normal Ss showed an initial, but relatively small, depression of intake on the 1st test day, but recovered to drink amounts approximating their pretest level on the 2nd test day and maintained their intake at this high level for the remaining days of the test. Thus, the exaggerated response to taste stimuli shown by hyperphagics is not restricted to the feeding situation; their response is at least as exaggerated in the drinking situation.