BOVINE GENERALIZED GLYCOGENOSIS

Abstract
The clinical, pathological, and biochemical features of a glycogen storage disease in beef cattle are described. The light and electron microscope changes in skeletal muscle, heart and the central nervous system were similar to the lesions that have been described in glycogenosis Type II, or Pompe's disease, in man. The stored intracytoplasmic material was shown histochemically and electron microscopically to be glycogen. Biochemical assay of liver, skeletal muscle, and heart demonstrated a deficiency of the lysosomal enzyme α‐1, 4‐glucosidase.