CYCLOPIA AND ARHINIA

Abstract

In spite of the brilliant researches in experimental embryology, the causal factors concerned with cyclopia in man still remain undetermined. In its most general phases, the problem has been resolved into factors of genesis, organization and mechanics. Nowhere is it clear as to the interrelation of these factors in producing the various degrees of optic and facial defects. Nor has a systematic chronologic investigation been made to determine the sequences necessary to produce the end results. The department of microscopic anatomy of this university has recently come into the possession of a specimen of cyclopia in a kitten, strikingly different from the 2 specimens of human cyclopia at hand. In the present paper I shall describe the face and the nasal and palatal rudiments as seen in the gross specimen, in roentgenograms and with the clearing method. Interest in the problem grew as it was realized that the common interpretation