Enhanced inhibition of RNA synthesis by amanitins in in vitro cultured cells
- 1 January 1976
- journal article
- specialia
- Published by Springer Nature in Cellular and Molecular Life Sciences
- Vol. 32 (1), 45-46
- https://doi.org/10.1007/bf01932615
Abstract
The inhibition of RNA synthesis by α-amanitin on vitro cultured cells is very slow. The action of various analogues of the toxin was tested and some of them proved more effective. Moreover pretreatment of cell cultures with DEAE-dextran greatly enhanced the effect of β-amanitin.Keywords
This publication has 12 references indexed in Scilit:
- Selective toxicity of amanitin-albumin conjugates for macrophagesCellular and Molecular Life Sciences, 1974
- Inhibition by α-amanitin of messenger RNA formation in cultured fibroblasts: Potentiation by amphotericin BExperimental Cell Research, 1973
- Inhibition of ribonucleic acid and of protein synthesis in the organs of rats and mice poisoned with α-amanitinBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973
- Toxicity of and Inhibition of RNA Polymerase by α-Amanitin Bound to Macromolecules by an Azo LinkageHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1973
- Impairment of herpesvirus growth in chick embryo fibroblast cultures by?-amanitinArchiv für die gesamte Virusforschung, 1971
- Inhibitory effect of naturally occurring and chemically modified amatoxins on RNA polymerase of rat liver nucleiFEBS Letters, 1971
- Amanitin binding to calf thymus RNA polymerase BFEBS Letters, 1970
- Amantis. Chemistry and actionFEBS Letters, 1970
- Studies on the pathogenesis of liver necrosis by α-amanitin. Effect of α-amanitin on ribonucleic acid synthesis and on ribonucleic acid polymerase in mouse liver nucleiBiochemical Journal, 1967
- über die Giftstoffe des grünen Knollenblätterpilzes, XIX. Umwandlung von β‐Amanitin in α‐AmanitinEuropean Journal of Organic Chemistry, 1960