A STUDY OF MICROLYMPHOIDOCYTIC LEUKEMIA

Abstract

PART 1 In 1915, Citron¹reported a case of leukemia which from the blood picture and clinical findings, was diagnosed as "micromyeloblastic leukemia." The postmortem histologic study carried out by Pappenheim and Citron showed that the bone marrow was entirely normal. However, the cells of the follicles, as well as the cells of the interfollicular tissue of the lymph nodes and spleen, contained a slightly enlarged, eccentrically placed, perfectly round nucleus which resembled very closely the nucleus of a "myeloblast." The largest forms, however, were not as large as those found in "myeloblastic leukemia." While the blood showed a definite myelogenous picture, it was evident that the "myeloblasts" and "micromyeloblasts" of the blood were not coming to any extent from the bone marrow because the bone marrow was normal (Pappenheim and Citron). On the other hand, there was clear evidence that an actual proliferation in situ of the follicular as