KINETICS OF ANTIBODY MEDIATED SUPPRESSION OF HUMORAL IMMUNE-RESPONSE TO TOXOPLASMA-GONDII AT A CELLULAR LEVEL

Abstract

The effect of passively transferred T. gondii [mouse] antiserum was examined at a cellular level by rosette forming cell response in NMRI mouse spleen. The initial number of responding rosette forming cells was decreased in antibody treated animals. However, their rate of proliferation in comparison to untreated group was not significantly affected. An almost similar response could be obtained by injecting 5 .times. 104 Toxoplasma organisms alone or a combining passive antibody and higher antigen dose of 1 .times. 106 parasites.