Operable Prostatic Carcinoma: Correlations Among Clinical Stage, Pathological Stage, Gleason Histological Score and Early Disease-Free Survival

Abstract

The relationships among clinical and pathological stages, Gleason histological score and early disease-free survival of 75 patients with localized prostatic carcinoma treated by radical prostatectomy were investigated. Carcinoma was confined histologically to the prostate in 81% of the patients with clinical stage A2, 79% with B1N, 38% with B1 and 0% with B2 tumors. The Gleason score correlated directly with clinical and pathological stages, estimated extent of intraprostatic tumor and invasive capacity of the primary tumor. Of the tumors with a Gleason score of 8 or more 81% extended beyond the prostatic capsule. Of 12 patients who suffered distant metastases 9 had tumors that extended beyond the prostatic capsule and 5 had tumors with Gleason scores of 8 or more.