The Biology of Cystitis: Host and Bacterial Factors
- 1 February 1999
- journal article
- review article
- Published by Annual Reviews in Annual Review of Medicine
- Vol. 50 (1), 149-158
- https://doi.org/10.1146/annurev.med.50.1.149
Abstract
Cystitis is caused by a relatively small number of bacterial species. To colonize and grow in the urinary tract, these organisms have developed and acquired special properties (virulence factors) that allow them to overcome the defences of the urinary tract, particularly clearance by urine flow. These virulence factors are unlikely to be required during transmission from host to host, and sometimes their constitutive expression may actually be disadvantageous. Such factors are therefore regulated by the environment and in a coordinate manner to ensure their most appropriate expression for the conditions encountered. This review focuses on the biology of the urinary tract and the bacterial properties necessary to cause cystitis. The regulation of virulence factors at the different stages of the infection is considered, and a general model for the pathogenesis of urinary tract infection is proposed.Keywords
This publication has 22 references indexed in Scilit:
- Dr Fimbriae Operon of UropathogenicEscherichia coliMediate Microtubule‐Dependent Invasion to the HeLa Epithelial Cell LineThe Journal of Infectious Diseases, 1997
- In vivo phase variation of MR/P fimbrial gene expression in Proteus mirabilis infecting the urinary tractMolecular Microbiology, 1997
- Induction of Gene Expression in Escherichia coli After Pilus-Mediated AdherenceScience, 1996
- tRNA genes and pathogenicity islands: influence on virulence and metabolic properties of uropathogenic Escherichia coliMolecular Microbiology, 1995
- Co‐ordinate expression of virulence genes during swarm‐cell differentiation and population migration of Proteus mirabilisMolecular Microbiology, 1992
- THE PREPUCE: A MISTAKE OF NATURE?The Lancet, 1989
- Antibacterial activity of human urineJCI Insight, 1968
- URINE AS A MEDIUM FOR BACTERIAL GROWTHThe Lancet, 1966
- KINETICS OF URINARY TRACT INFECTIONBritish Journal of Urology, 1966
- KINETICS OF URINARY TRACT INFECTIONBritish Journal of Urology, 1966