A Short and Efficient Diastereoselective Synthesis of 2′-Substituted 2- Cyclopropylglycines

Abstract
Diastereomerically pure 2-cyclopropylglycines 2, 2′-substituted with an electron-withdrawing group, were prepared in two steps by Michael addition of the glycine equivalent 2-(diphenylmethyleneamino)acetate 11 to various Michael acceptors of type 1 with subsequent γ-elimination of bromide and followed by acid mediated deprotection.