DNA Polymerase β Inhibitors from Sandoricum koetjape
- 24 July 1999
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 62 (8), 1110-1113
- https://doi.org/10.1021/np990104r
Abstract
Bioassay-guided fractionation of Sandoricumkoetjape using an assay sensitive to DNA polymerase β inhibition led to the isolation of three active compounds (1−3) having IC50 values from 20 to 36 μM. Derivatives 5−14 were prepared from compounds 1 and 2; derivatives 11, 12, and 13 showed activity against DNA polymerase β with IC50 values ranging from 16 to 36 μM.This publication has 18 references indexed in Scilit:
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