Antibiotics Alter Methotrexate Metabolism and Excretion
- 14 November 1969
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 166 (3907), 887-888
- https://doi.org/10.1126/science.166.3907.887
Abstract
The chemotherapeutic agent methotrexate is metabolized by the intestinal flora of normal mice. This metabolism is reduced either by treatment of mice with the antibiotics neomycin and sulfathiazole, or in germ-free mice. In addition to affecting metabolism, these antibiotics alter physiological distribution of methotrexate so that excretion by the intestinal route is significantly enhanced.Keywords
This publication has 7 references indexed in Scilit:
- Drug Metabolism by Intestinal MicroorganismsJournal of Pharmaceutical Sciences, 1968
- The enzymatic hydrolysis of folate analoguesBiochemical Pharmacology, 1968
- The relative toxicities of methotrexate and aminopterinBiochemical Pharmacology, 1966
- Resistance of the rabbit to methotrexate: Isolation of a drug metabolite with decreased cytotoxicityBiochemical Pharmacology, 1966
- Methotrexate Displacement in Man*JCI Insight, 1964
- Chromatographic Separation and Purification of Folic Acid AnalogsAnalytical Chemistry, 1961
- An experimental malabsorption syndrome induced by neomycinAmerican Journal Of Medicine, 1960