Granulocyte Progenitor Compartments after Allogeneic Bone Marrow Grafts

Abstract

Bone marrow granulocyte colony forming cells (CFU‐C) were measured in 10 HL'A compatible sibling donor‐recipient pairs. The regeneration of granulocytes and CFU‐C compartments were also studied in order to evaluate haemopoietic recovery. The number of nucleated bone marrow cells in the donation was 23 ±4 times 10⁹ cells, which recipients received (3.5 ±0.4) × 10⁸ nucleated cells/kg and (1.19 ±0.32) × 10⁵ CFU‐C/kg. This produced a bone marrow reconstitution of (67 ±26) × 10⁵ CFU‐C/kg by day 30. There was a significant correlation between CFU‐C/kg given and (1) granulocyte count on day 30 (P = < 0.05) and (2) the first day of reappearance of neutrophils in the blood (P = < 0.05). a significant correlation between CFU‐C/kg given and (1) granulocyte count on day 30 (P = < 0.05) and (2) the first day of reappearance of neutrophils in the blood (P = < 0.05). These results indicate that the speed and completeness of granulocyte regeneration can be predicted by measurement of the size of the CFU‐C inoculant in the bone marrow graft.