Conditions for Bacille Calmette-Guerin-Induced Resistance to Infection with Schistosoma mansoni in Mice
- 1 May 1978
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 137 (5), 550-555
- https://doi.org/10.1093/infdis/137.5.550
Abstract
Intravenous administration of a lyophilized preparation of bacille Calmette-Guérin (BCG-Tice) into mice significantly protected these animals from infection with Schistosoma mansoni. The protective effect depended on the dose of BCG and required the administration of at least 2 × 107 viable organisms. The route of administration of BCG was also crucial, as only intravenous inoculation produced significant protection. The BCG-induced resistance was found to last for eight weeks. Significant inflammation of the lungs was observed in mice receiving either viable or heat-killed BCG; however, protection followed only the administration of viable bacilli. Expression of BCG-induced protection was dependent on the presence of significant numbers of viable organisms and may have been associated with pulmonary inflammation at the time of passage of the schistosomula through the lungs.Keywords
This publication has 6 references indexed in Scilit:
- Genetic Differences in BCG-Induced Resistance to Schistosoma Mansoni Are not Controlled by Genes within the Major Histocompatibility Complex of the MouseThe Journal of Immunology, 1978
- Effect of treatment with BCG on the course of visceral leishmaniasis in BALB/c miceInfection and Immunity, 1977
- STRAIN VARIATION IN BCG-INDUCED CHRONIC PULMONARY INFLAMMATION IN MICE .1. BASIC MODEL AND POSSIBLE GENETIC-CONTROL BY NON-H-2 GENES1977
- Comparison of Penetration and Maturation of Schistosoma Mansoni in the Hamster, Mouse, Guinea Pig, Rabbit, and Rat *The American Journal of Tropical Medicine and Hygiene, 1967
- Effects of Oil-treated Mycobacterial Cell Walls on the Organs of MiceJournal of Bacteriology, 1967
- THE IMMUNOLOGICAL BASIS OF ACQUIRED CELLULAR RESISTANCEThe Journal of Experimental Medicine, 1964