ACTION OF TRYPSIN AND PAPAIN ON DERIVATIVES OF DIAMINOBUTYRIC ACID, ORNITHINE AND LYSINE

Abstract

[longdash]Benzoyl-L-lysinamide and benzoyl-L-argininamide are hydrolyzed by trypsin and acetyltrypsin, and benzoyl-L-ornithine only by trypsin, while [alpha]-benzoylamino-[gamma]-aminobutyramide is not susceptible to these enzymes. All 4 substrates are hydrolyzed by papain. Spontaneous hydrolysis of the methyl esters of the above compounds proceeded rapidly at pH 7.8 to form 5- or 6-membered lactams.