A new enantiodivergent procedure utilising the chemoselective dieckmann-type cyclisation of chiral mono-thiol diesters

Abstract

The chiral mono-thiol diester, 1 or 2, is converted to the corresponding enantiomeric cyclised products,(–)-7 and (+)-7 or (–)-9, and (+)-9, depending on whether LDA or AlCl₃–Et₃N is used.