C. elegans lin-45 raf gene participates in let-60 ras-stimulated vulval differentiation
- 1 May 1993
- journal article
- Published by Springer Nature in Nature
- Vol. 363 (6425), 133-140
- https://doi.org/10.1038/363133a0
Abstract
Vulval differentiation in Caenorhabditis elegans is controlled by intercellular signalling mediated by a receptor tyrosine kinase and a ras gene product. The lin-45 gene encodes a homologue of the raf family of serine/threonine kinases and is necessary for vulval differentiation. The lin-45 raf gene product appears to act downstream of the ras protein in this pathway. A proto-oncogene-mediated signalling pathway may be a common feature of metazoan development.Keywords
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