APPRAISAL OF THE GOITROGENS: RESULTS OF TREATMENT WITH THIOURACIL, PROPYLTHIOURACIL AND RELATED ANTITHYROID DRUGS*
- 1 September 1948
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 8 (9), 766-775
- https://doi.org/10.1210/jcem-8-9-766
Abstract
The author reviews the use of the anti-thyroid drugs in the treatment of hyperthyroidism. Dosage ranges from 200 mg. per day (methyl or propylthiouracil) to 600 mg. per day (thiouracil). A summary of reports on the toxicity of these drugs shows thiouracil and methylthiouracil to be the most (10%) and propylthiouracil the least (about 2%) toxic. The greatest danger in their use is in the development of white blood cell depression. The use of antithyroid medication to bring the patient into a euthyroid state before surgery is strongly recommended and is probably the site of greatest usefulness of these drugs. Antithyroid medication vs. surgery in the treatment of hyperthyroidism is discussed in relation to permanence of cure and complications attendant on each method of treatment.Keywords
This publication has 6 references indexed in Scilit:
- DETERMINATION OF THE RELATIVE ACTIVITIES OF ANTITHYROID COMPOUNDS IN MAN USING RADIOACTIVE IODINE1Endocrinology, 1947
- TOXIC EFFECTS OF THIOUREA, THIOURACIL, METHYL THIOURACIL, AND AMINOTHIAZOLE IN THYROTOXICOSISThe Lancet, 1947
- TREATMENT OF HYPERTHYROIDISM WITH PROPYLTHIOURACILAnnals of Internal Medicine, 1946
- THYROTOXICOSIS TREATED WITH THIOURACIL AND METHYL THIOURACILThe Lancet, 1946
- TOXIC MANIFESTATIONS OF THIOURACIL THERAPYJAMA, 1946
- TREATMENT OF HYPERTHYROIDISM WITH THIOUREA AND THIOURACILJAMA, 1943