Prediction of clinical course of bipolar manic depressive illness treated with lithium
- 1 May 1980
- journal article
- research article
- Published by Cambridge University Press (CUP) in Psychological Medicine
- Vol. 10 (2), 329-334
- https://doi.org/10.1017/s0033291700044093
Abstract
SYNOPSIS A group of bipolar manic depressive patients attending a routine lithium clinic were investigated. The results suggest that, when on treatment with lithium, manic depressive patients with a good prognosis tend to have a higher erythrocyte Na-K ATPase and higher plasma and erythrocyte lithium concentrations than those with a poor prognosis. There was no evidence to suggest that the erythrocyte: plasma lithium ratio was useful in predicting clinical response to lithium therapy. There was also a positive correlation between plasma lithium concentration and Na–K ATPase activity, confirming that in manic depressive subjects lithium produces a rise in erythrocyte Na–K ATPase activity.Keywords
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