Preparation and properties of derivatives of virginiamycin S.

Abstract

Reduction of virginiamycin S with sodium borohydride produces allo- and n-dihydrovirginiamycin S. Reduction of the tosylhydrazone of virginiamycin S with sodium cyanoborohydride affords deoxyvirginiamycin S. These compounds are less active than virginiamycin S. Like virginiamycin S they enhance the activity of virginiamycin M1.