Na+ + Cl−‐gradient‐driven, high‐affinity, uphill transport of taurine in human placental brush‐border membrane vesicles
- 11 April 1988
- journal article
- Published by Wiley in FEBS Letters
- Vol. 231 (1), 263-267
- https://doi.org/10.1016/0014-5793(88)80744-0
Abstract
Uptake of taurine in human placental brush-border membrane vesicles was greatly stimulated in the presence of an inwardly-directed Na+ + Cl−-gradient and uphill transport of taurine could be demonstrated under these conditions. Na+ as well as Cl− were obligatory for this uptake and both ion gradients could energize the uphill transport. This Na+ + Cl−-gradient-dependent taurine uptake was stimulated by an inside-negative membrane potential, demonstrating the electrogenicity of the process. The uptake system was highly specific for β-amino acids and the K m of the system for taurine was 6.5 ± 0.4 μM.Keywords
This publication has 13 references indexed in Scilit:
- Sodium-gradient-driven, high-affinity, uphill transport of succinate in human placental brush-border membrane vesiclesBiochemical Journal, 1988
- Interaction of clonidine with human placental Na+-H+ exchangerBiochemical Pharmacology, 1986
- Characterization of tryptophan transport in human placental brush-border membrane vesiclesBiochemical Journal, 1986
- TAURINE: BIOLOGICAL UPDATEAnnual Review of Biochemistry, 1986
- Transport of amino acids in the placentaBiochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1985
- Dipeptide transport in brush-border membrane vesicles isolated from normal term human placentaAmerican Journal of Obstetrics and Gynecology, 1985
- Factors affecting the transport of β-amino acids in rat renal brush-border membrane vesicles. The role of external chlorideBiochimica et Biophysica Acta (BBA) - Biomembranes, 1985
- Transport of glycyl-L-proline into intestinal and renal brush border vesicles from rabbit.Journal of Biological Chemistry, 1981
- Taurine in developmentLife Sciences, 1977
- Taurine in Developing Rat BrainPediatric Research, 1977