Amino-acids and peptides. Part XXXVII. Trifluoroacetylation during the coupling of t-butoxycarbonylamino-acids with peptide esters in the presence of trifluoroacetate anion

Abstract

The use of dicyclohexylcarbodi-imide to form peptide bonds in the presence of trifluoroacetate anion can cause substantial trifluoroacetylation of the amino-component. The addition of 1-hydroxybenzotriazole greatly reduces or eliminates this side-reaction.