Unsuccessful trial of gene replacement in arginase deficiency
- 1 March 1975
- journal article
- Published by Springer Nature in European Journal of Pediatrics
- Vol. 119 (1), 1-3
- https://doi.org/10.1007/bf00464689
Abstract
The Shope virus following cutaneous inoculation produces skin papillomas in rabbits and induces a virus-coded arginase in the squameous epithelium of these papillomas. The only discernible effect of the virus inoculated intravenously in rabbits and other animals was a decrease of the serum arginine concentration. Intravenous injection in 3 hyperargininemic patients, however, did not influence the underlying metabolic disease. Das Shope-Virus induziert nach cutaner Inoculation bei Kaninchen die Bildung von Papillomen. Die genetische Information für die Bildung der in den Papillomepithelien enthaltenen Arginase entstammt dem Virusgenom. Nach intravenöser Injektion des Virus findet sich beim Kaninchen und zahlreichen anderen Tierspecies als einziger Effekt ein Abfall der Argininkonzentration in Serum. Bei 3 Patienten mit Hyperargininämie, denen das Shope-Virus ebenfalls intravenös injeziert wurde, blieben die hohen Argininkonzentrationen im Serum unbeeinflußt.Keywords
This publication has 14 references indexed in Scilit:
- INDUCTION OF ARGINASE ACTIVITY WITH THE SHOPE PAPILLOMA VIRUS IN TISSUE CULTURE CELLS FROM AN ARGININEMIC PATIENTThe Journal of Experimental Medicine, 1973
- Gene Therapy for Human Genetic Disease?Science, 1972
- CHANGE IN THE STRUCTURE OF SHOPE PAPILLOMA VIRUS-INDUCED ARGINASE ASSOCIATED WITH MUTATION OF THE VIRUSThe Journal of Experimental Medicine, 1971
- Hyperargininämie mit Arginasedefekt Eine neue familiäre StoffwechselstörungEuropean Journal of Pediatrics, 1970
- Hyperarginin mie mit Arginasedefekt Eine neue famili re Stoffwechselst rungEuropean Journal of Pediatrics, 1970
- ARGININÆMIA WITH ARGINASE DEFICIENCYThe Lancet, 1969
- Shope Papilloma Virus: A Passenger in Man and its Significance to the Potential Control of the Host GenomeNature, 1966
- STUDIES OF THE MECHANISM OF ACTION OF THE SHOPE RABBIT PAPILLOMA VIRUSThe Journal of Experimental Medicine, 1963
- Induction of Arginase in Rabbit Epithelium by the Shope Rabbit Papilloma VirusNature, 1959
- A Complement-Fixation Reaction Involving the Rabbit Papilloma Virus (Shope)Experimental Biology and Medicine, 1937