Clinical Studies on the Activity of Orally Administered Cortisone
- 11 October 1951
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 245 (15), 549-555
- https://doi.org/10.1056/nejm195110112451501
Abstract
AS EARLY as the end of the last century there were indications in the literature that adrenal cortical hormones were effective when given orally. Notable among these was a report by Osler in 1896 of a patient with Addison's disease who appeared to respond clinically to a glycerol extract of hog adrenal glands.1 In 1931 Britton and Silvette2 , 3 demonstrated conclusively that an orally administered adrenal extract could provide adequate substitution therapy in adrenalectomized cats. It was logical, then, that cortisone, once available in quantity, should be tried by a route that offers so many clinical advantages.The clinical effectiveness of . . .Keywords
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