Tierexperimentelle untersuchungen zur beeinflussung der wundheilung durchCandida albicans
- 1 January 1976
- journal article
- research article
- Published by Springer Nature in Archives of Dermatological Research
- Vol. 256 (2), 205-212
- https://doi.org/10.1007/bf00567366
Abstract
An Ratten wurde der Einfluß vonCandida albicans auf die Wundheilung untersucht. Als Parameter galt die Entwicklung von Granulationsgewebe in PVC-Kammern, die den Tieren in standardisierte Wunden am Rücken implantiert worden war.Candida albicans hemmt in diesem Modell die Wundheilung signifikant. Der Hemmeffekt ist proportional zur Hefekonzentration und an die Gegenwart lebender Hefezellen gebunden. Auf Grund dieser Ergebnisse wird angenommen, daß die Hefebesiedlung von Ulcera cruris beim Menschen pathogene Bedeutung haben kann und möglicherweise deren Heilungsverlauf beeinflußt. The effects ofCandida albicans on the healing of experimental wounds in rats was investigated. Granulation tissue developing in implanted polyvinylchloride chambers was quantified. The amount of granulation tissue in the yeast-contaminated wounds is significantly less in comparison to controls. The inhibitory effect is directly proportional to the amount of inoculated yeasts and dependes on the presence of living yeast cells. The repair of ulcers is supposedly retarded by yeast contamination, as has been suggested previously by clinical observation.This publication has 20 references indexed in Scilit:
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