Hepatic Glutaminase Flux Regulation of Glutamine Homeostasis. Studies in vivo
- 1 January 1986
- journal article
- research article
- Published by Walter de Gruyter GmbH in Biological Chemistry Hoppe-Seyler
- Vol. 367 (1), 301-306
- https://doi.org/10.1515/bchm3.1986.367.1.301
Abstract
The role of hepatic glutaminase flux in regulating plasma glutamine homeostasis was studied in the intact rat. 1) Interorgan glutamine flow during chronic metabolic acidosis was away from the splanchnic bed and to the kidneys. Hindquarter and hepatic glutamine release were the major sources of glutamine removed by the kidneys. 2) Interorgan glutamate flow was from the liver to the hindquarters and kidneys. 3) Chronic metabolic acidosis reduced arterial glutamine concentration 30%. 4) Acute respiratory acidosis (pH 7.12 .+-. 0.02) returned arterial glutamine concentration to normal values, increasing and decreasing hepatic glutamine and glutamate release respectively; renal and gut glutamine removal rates were not decreased. 5) Hepatic unidirectional glutamine utilization measured isotopically was decreased 51% by acute acidosis; unidirectional glutamine production was unchanged. The results are consistent with the proposed role of ammonia-activated hepatic glutaminase in the regulation of glutamine homeostasis during acute acidosis.This publication has 11 references indexed in Scilit:
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