Early rise of cytosolic Ca2+ induced by NGF in PC12 and chromaffin cells
- 10 November 1986
- journal article
- Published by Wiley in FEBS Letters
- Vol. 208 (1), 48-51
- https://doi.org/10.1016/0014-5793(86)81529-0
Abstract
A rise of cytosolic Ca2+ is induced by NGF in rat pheochromocytoma PC12 and bovine chromaffin cells investigated (both in suspension and while attached to polyornithine-coated glass slides) by fluorescence techniques (with quin-2 and fura-2). The effect of NGF on [Ca2+]i is delayed (30–40 s of lag phase), slow (tf1/2 = 40 s), relatively small (+50-75%) and persistent (over 10 min). It is due to Ca2+ influx (requires extra-cellular Ca2+ > 10 μM) through a pathway different from the voltage-gated Ca2+ channel, possibly accompanied by intracellular Ca2+ redistribution, and might play a messenger role in NGF actionKeywords
This publication has 17 references indexed in Scilit:
- Effect of Adenosine, Adenosine Derivatives, and Caffeine on Acetylcholine Release from Brain Synaptosomes: Interaction with Muscarinic Autoregulatory MechanismsJournal of Neurochemistry, 1986
- The role of cAMP in nerve growth factor-promoted neurite outgrowth in PC12 cells.The Journal of cell biology, 1986
- Nerve growth factor is a mitogen for cultured chromaffin cellsNature, 1985
- Inositol trisphosphate, a novel second messenger in cellular signal transductionNature, 1984
- Comparison of rapid changes in surface morphology and coated pit formation of PC12 cells in response to nerve growth factor, epidermal growth factor, and dibutyryl cyclic AMP.The Journal of cell biology, 1984
- Ionic responses and growth stimulation induced by nerve growth factor and epidermal growth factor in rat pheochromocytoma (PC12) cells.The Journal of cell biology, 1983
- Ca2+ transmembrane fluxes and nerve growth factor action on a clonal cell line of rat phaeochromocytomaNature, 1980
- Properties of the nerve growth factor receptor of a clonal line of rat pheochromocytoma (PC12) cellsExperimental Cell Research, 1979
- Post‐synaptic PI‐effect of nerve growth factor in rat superior cervical gangliaJournal of Neurochemistry, 1979
- Alterations in the surface properties of cells responsive to nerve growth factorNature, 1978