Effect of Spheronization Technique on Drug Release from Uncoated Beads

Abstract

Spheronization techniques are finding increased utility in pharmaceutical research and production. In this investigation emphasis is on the effect of two different spheronization methods (pan versus marumerizer) on drug release from uncoated beads containing acetaminophen and microcrystalline cellulose at a 1:1 ratio. Drug release from the pan beads is much faster than that from the marumerizer beads. The pan beads disintegrate during the dissolution testing, while beads made via the extruder and marumerizer appear to behave as an inert matrix system.