Presenile Cataract Formation and Decreased Activity of Galactosemic Enzymes
- 1 February 1980
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of Ophthalmology (1950)
- Vol. 98 (2), 269-273
- https://doi.org/10.1001/archopht.1980.01020030265003
Abstract
• One hundred forty-seven patients, 144 with advanced cataract formation, had determinations of erythrocyte galactokinase and galactose-1-phosphate uridyl transferase performed. Significant reduction (more than 2 SDs) of one of these enzymes was found in 47.4% of patients 50 years old or less with presenile "idiopathic" bilateral cataracts, 7.1% of other patients with cataracts aged 50 years or less, and 3.8% of patients with cataracts aged 51 years or more. The differences between the group with presenile idiopathic cataracts and the other groups were statistically highly significant (P <.001). Patients with reduced activity of galactokinase or galactose-1-phosphate uridyl transferase (presumed heterozygotes) compose about 1% of the general population, appear to be more susceptible to idiopathic presenile cataract formation, and may be more prone to secondary cataract formation after a variety of lenticular insults. Dietary restriction of milk and milk products may prevent or delay cataract formation in these individuals.This publication has 14 references indexed in Scilit:
- Newborn screening for galactosemia and other galactose metabolic defectsThe Journal of Pediatrics, 1978
- GALACTOKINASE AND CATARACTSThe Lancet, 1978
- A new genetic variant of galactose-1-phosphate uridyl transferaseHuman Genetics, 1976
- Galactokinase deficiency: Clinical and biochemical findings in a new kindredThe Journal of Pediatrics, 1972
- Cataracts and Galactokinase DeficiencyNew England Journal of Medicine, 1972
- Galactokinase Deficiency and CataractsAmerican Journal of Ophthalmology, 1972
- Unstable galactose-1-phosphate uridyl transferase: A new variant of galactosemiaThe Journal of Pediatrics, 1971
- Detection of heterozygotes for galactokinase deficiency in a human populationBiochemical Genetics, 1968
- DEFICIENCY OF ERYTHROCYTE GALACTOKINASE IN A PATIENT WITH GALACTOSE DIABETESThe Lancet, 1965
- Variability in the clinical manifestations of galactosemiaThe Journal of Pediatrics, 1961