Synthesis of Carbapenam Skeletons Using a Ruthenium-Catalyzed Cyclization
- 13 September 2000
- journal article
- letter
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 2 (20), 3245-3247
- https://doi.org/10.1021/ol006510f
Abstract
Carbapenam is a very important skeleton of β-lactam antibiotics, and it has a highly strained structure. When enynes 9 were treated with RuH2CO(PPh3)3 (10 mol %) in toluene upon heating, carbapenams 10 were obtained in good yields.Keywords
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