FEATURES OF IMMUNE-RESPONSE TO DNA IN MICE .2. PARTICIPATION OF B-CELLS AND T-CELLS
- 1 January 1976
- journal article
- research article
- Vol. 26 (1), 52-56
Abstract
The respective roles of thymus-derived [T] and bone marrow-derived lymphocytes in the immune response to DNA was investigated in mice reconstituted with various cell populations using cell transfers. A helper effect of T cells in the immune response to DNA was suggested by experiments performed in athymic nude BALB/c mice. Reconstitution experiments performed in low responder DBA/mice indicated that the immune response to DNA can be increased after transfer of bone marrow cells from high responder NZB mice, even in the presence of thymocytes from DBA/2 mice. In NZB .times. NZW mice, a major role of bone marrow cells, with a possible modulation by T cells during aging, was observed in the spontaneous development of anti-DNA antibodies.This publication has 12 references indexed in Scilit:
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