Susceptibility of Nontypeable Haemophilus influenzae to Human β-Defensins Is Influenced by Lipooligosaccharide Acylation
Open Access
- 1 September 2002
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 70 (9), 5287-5289
- https://doi.org/10.1128/iai.70.9.5287-5289.2002
Abstract
Nontypeable Haemophilus influenzae (NTHI) lipooligosaccharide htrB mutants exhibited greater than 45-fold-increased sensitivity to human β-defensin 2 (HBD-2) compared to the wild type. Complementation by htrB in trans to acylation competence reversed this increased sensitivity. In contrast, NTHI was more susceptible to HBD-3 and showed no changes in sensitivity as a result of lipooligosaccharide mutations in oligosaccharide and lipid A biosynthesis genes.Keywords
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