Comparison of Diphosphonate Effects on Enamel in vitro and in vivo

Abstract

Enamel [from bovine incisor] was exposed to disodium ethane-1,1-diphosphonate solutios (EHDP) in vitro and in vivo. EHDP inhibited remineralization in vitro, but increased the resistance against acid when incorporated in the enamel. In vivo, EHDP acted differently. This may be explained by additivity of the effect of EHDP on acid formation in plaque and the effect of surface active salivary molecules to the inhibition of EHDP on de- and remineralization as was found in the in vitro experiments.