Experimental Chemotherapy of Burns and Shock. IV. Production of Traumatic Shock in Mice. V. Therapy with Mouse Serum and Sodium Salts

Abstract

A method of producing traumatic shock in mice, based upon the tourniquet technique, has been developed. The mortality in 127 untreated animals was 95%. Saline possessed a curative effect similar to that previously demonstrated in burn shock (Pub. Health Rep. 58: 513 (1943)). Survival > 90% could be obtained from isotonic NaCl given intraven., intraperit. or orally, in amts. of approx. 10% of body wt. The effectiveness of blood serum was shown to be due to its electrolyte content: [long dash](a) it was slightly less active than 0.9% saline; (b) serum was as active by mouth as intraven. (c) a protein-free ultra-filtrate of serum was as active as the original serum, both administered intraven.