Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules
- 1 May 1991
- journal article
- research article
- Published by Springer Nature in Nature
- Vol. 351 (6324), 290-296
- https://doi.org/10.1038/351290a0
Abstract
The crystal structures of major histocompatibility complex (MHC) molecules contain a groove occupied by heterogeneous material thought to represent peptides central to immune recognition, although until now relatively little characterization of the peptides has been possible. Exact information about the contents of MHC grooves is now provided. Moreover, each MHC class I allele has its individual rules to which peptides presented in the groove adhere.Keywords
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